Clinical and prognostic features of adult patients with gangliogliomas. Phase I adult brain tumor consortium (ABTC) trial of ABT-888 (veliparib), temozolomide (TMZ), and radiotherapy (RT) for newly ...
There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied ...
Maintenance of steady-state levels of the tumor suppressor p53 is very dependent on its interaction with Mdm2. This multifunctional protein antagonizes p53 activity by inhibition of p53-dependent ...
The mammalian CDKN2A locus contains a gene encoding two unrelated proteins; the cyclin-dependent kinase inhibitor p16 INK4a and ARF — a regulator of p53 stability. In the Early Edition of the ...
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