Nature

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

How SARS-CoV-2 Omicron evolved remains obscure. T492I, an Omicron-specific mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters nonstructural ...
Nature

An orthogonal transcription mutation system generating all transition mutations for accelerated protein evolution in vivo

Targeted mutagenesis systems are critical for protein evolution. Current deaminase-T7 RNA polymerase fusion systems enable gene-specific mutagenesis but remain limited to certain model organisms. Here ...
iaea.org

Induced Mutation for Accelerated Varietal Development in Cowpea for Africa

Climate change is impacting food production globally. With an ever-increasing global population and changing diets, the demand for pulses and grain legumes is rising swiftly. In the mixed and agro- ...
The American Journal of Managed Care

Multi-Hit TP53 Mutations Linked With Poor Outcomes in MPN, AML

Multi-hit TP53 mutations are linked to poor survival in both MPN and AML, with median OS ranging from 4.8 to 11.6 months. Factors such as ASCT, pre-transplant therapy response, and concurrent TET2 or ...