Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies.

Golgi membrane-associated degradation (GOMED) selectively degrades proteins by using K33-linked polyubiquitin as an 'eat-me' signal, which is recognized by the adaptor protein optineurin (OPTN). Mice ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Proteins perform nearly every function in a cell. It seems intuitive that cells are constantly making proteins so they can perform the tasks necessary to sustain life. Less intuitive, perhaps, is that ...

Macquarie University neuroscientists have developed a single-dose genetic medicine that has been proven to halt the progression of both motor neuron disease (MND) and frontotemporal dementia (FTD) in ...

The environment in which breast cancer arises—the interplay between the patient's BMI, tumor size and cancer-specific proteins—is of importance for the prognosis. This is shown in a study from Lund ...