Chromatin remodeling encompasses dynamic alterations to nucleosome composition, positioning and structure that enable or restrict access to genomic DNA. In plants, ATP-dependent remodelling complexes ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

A new study by Dr. Tian Ye's group from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS) has revealed that mitochondrial stress coordinates chromatin ...

Research published in Cell Research from Mario Halic, PhD, St. Jude Department of Structural Biology, revealed 13 distinct structures of the chromatin remodeler SNF2H offering a comprehensive view the ...

The simplest explanation of cancer is that, for any reason, a cell in our body ignores its biological program and gets loose, multiplying itself again and again, creating a tumor. This has a lot to do ...

Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin ...

Chromatin remodelers are ATP-dependent motor proteins that dynamically reorganize chromatin architecture, playing essential roles in gene expression, development, and immune function. Dysregulation of ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated. When this fails, the wrong ...

Taking unconventional paths with no fear of exploring the unknown has been a hallmark of Cigall Kadoch’s work. As a graduate student, the now biochemist and molecular biologist joined a developmental ...

Our cells are usually frantically working to sustain life. Part of this work includes dividing, a process that creates more cells to support our growth when we are children or to replace old, worn-out ...

A major obstacle to durable cancer treatment is the ability of tumor cells to survive therapeutic pressure without acquiring genetic mutations. Rather than ...