Clonidine is an α 2 adrenoceptor agonist that is frequently used to reduce withdrawal symptoms during opioid detoxification in humans. The long-term effects of clonidine on withdrawal symptoms and its ...

Pediatric researchers at the University of Kentucky found that clonidine, an antihypertensive drug typically used to treat high blood pressure, can be as effective as morphine in treating neonatal ...

Length of treatment and neurobehavioral scores did not significantly differ between infants with prenatal opioid exposure randomized to either clonidine or morphine, researchers found. Among infants ...

A randomized clinical trial compared tramadol extended-release with clonidine and buprenorphine for the management of opioid withdrawal symptoms in patients with opioid use disorder in a residential ...

Previous pharmacological studies have implicated serotonergic brain systems in opiate-withdrawal-precipitated conditioned place aversion. To assess this hypothesis, we tested the effects of either (i) ...

Objective: To evaluate literature reporting on the role of norepinephrine in alcohol withdrawal and to determine the safety and efficacy of α 2-agonists in reducing symptoms of this severe condition.

Extended-release formulations of tramadol hydrochloride (tramadol ER) (multiple brands) may provide an alternative treatment option for reducing withdrawal symptoms in patients with opioid use ...