Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

Researchers at The University of Texas MD Anderson Cancer Center have performed a comprehensive evaluation of five artificial intelligence (AI) models trained on genomic sequences, known as DNA ...

The DNA foundation model Evo 2 has been published in the journal Nature. Trained on the DNA of over 100,000 species across the entire tree of life, Evo 2 can identify patterns in gene sequences across ...

The thermodynamics of DNA secondary structure formation is fundamental to understanding diverse biological processes, such as DNA replication 1 and repair 2. It also underlies many biotechnological ...

Most people are familiar with the DNA double-helix. Its twisted ladder shape forms because the long pieces of DNA that make up our genome are exactly complementary—every adenine paired to a thymine, ...

A joint research team has developed an automated design technology that enables the creation of DNA origami structures that ...

*Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or ...

Genome annotation models play a pivotal role in modern biological research, providing the tools necessary to identify genes, their exon–intron structure and other functional elements directly from DNA ...

In a recent study published in the journal Nature, researchers at the Arc Institute describe the development and advantages of “Evo 2”. Evo 2 is a novel biological foundation model trained on a ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...