Nature

DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides

Moreover, it enables the measurement of the effects of methylated cytosines if they are installed in the DNA template used for replication. PER-seq is extremely sensitive, with the ability to detect ...
Nature

Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. These mutations have been attributed to deamination of 5-methylcytosine (5mC), an ...