Fatty acid and polyketide biosynthesis share a modular enzymatic architecture that assembles acyl building blocks into complex molecules via successive chain‐elongation and modification reactions. In ...

The alternative text for this image may have been generated using AI. Fig. 2: Module and domain organization of VEMS, split VEMS, and AT/MAT-swapping in modules of VEMS, PIKS, and DEBS. The ...

The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...

Medium- and short-chain fatty acids (C8-C14) are widely used in industries including food, pharmaceuticals, lubricants, and surfactants, and they are currently mainly extracted from coconut and palm ...

Diacylglycerol O-acyltransferase 1 (DGAT1), the rate-limiting enzyme in triacylglycerol (TAG) biosynthesis, is a crucial target for engineering plants with higher oil yields and improved oil quality.

Farnesyl transferase inhibitor (FTI) darlifarnib (KO-2806) in combination with adagrasib in KRAS G12C mutated (mut) advanced solid tumors: Preliminary results from the FIT-001 phase 1 first-in-human ...