Obesity increases the body's need for insulin, forcing cells in the pancreas known as beta cells to ramp up insulin ...

Diabetes is a lifelong, chronic health condition caused by abnormalities in the body’s production and use of the hormone insulin. Research has shown that the feel-good hormone, dopamine (DA), plays a ...

Researchers elucidate how BHLHE40, a transcriptional repressor activated in pancreatic β-cells as a response to hypoxia, inhibits the expression of the MAFA protein, thereby leading to impaired ...

Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control ...

How does the body regulate the activity of insulin-producing cells in order to react quickly to changing conditions? Researchers have investigated this question. The hormone insulin plays a central ...

Researchers show that obesity alters pancreatic cells to produce cholecystokinin, which drives cancer growth, revealing new links between hormone signaling, cellular stress, and tumor risk.

Researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little. Just over a century has passed since the ...

When lipid biologist Usha Acharya at the National Cancer Institute (NCI) tinkered with lipid breakdown pathways in Drosophila melanogaster, she observed something intriguing. Blocking a biochemical ...

GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...