Ak4 regulates mitochondrial DNA synthesis to control macrophage antibacterial activity, research finds

A mitochondrial enzyme, Ak4, strengthens immune defense by promoting mitochondrial DNA synthesis and enhancing macrophage ...
Kaleido Scope

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal function

Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...
News Medical

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

As a chronic pro-inflammatory disease, obesity is closely associated with the development of various diseases such as type 2 diabetes, cardiovascular disease and cancers. Obesity is now a major ...
EurekAlert!

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal function

The understanding of how macrophages regulate their response to toxic particles via two independent pathways could uncover therapeutic opportunities to quell inflammation BIRMINGHAM, Ala. – Human ...