Nature

The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria

Breast cancer cells often show increased activity of the mitogen-activated protein kinase (MAPK) pathway. We report here that this pathway reduces their sensitivity to death ligand tumor necrosis ...
Nature

Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells

EC (stages IA and IB) samples were obtained from 11 women, aged 45–60 years. Control endometria of secretory phase were derived from 10 women with uterine leiomyomas who underwent hysterectomy, aged ...
ascopubs.org

Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer

Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005 Next-generation sequencing was used to analyze this patient's ...
ascopubs.org

Mechanisms of Resistance to Mitogen-Activated Protein Kinase Pathway Inhibition in BRAF-Mutant Melanoma

Anticancer drug resistance remains a crucial impediment to the care of many patients with cancer. Although the exact mechanisms of resistance may differ for each therapy, common mechanisms of ...
Becker's Hospital Review

Sunquest Information Systems Announces the General Availability of Sunquest Mitogen: Molecular LIMS

Announcing a new world-class, comprehensive, and flexible platform to simplify and streamline molecular diagnostics laboratory management and genetic analysis and reporting for precision medicine – ...