Engagement of intracellular targets is often critical to drug mechanisms. Establishing a target engagement (TE) profile is an important step in small- molecule drug discovery as well as chemical probe ...

Kinases constitute a family of more than 500 enzymes and play critical roles in cellular signaling, both in normal and diseased cells. As a result, kinases continue to be key drug targets, especially ...

Bioluminescent assays are essential tools for tracking protein activity, cell signaling pathways and cellular dynamics. These assays provide high sensitivity, low background noise, and flexibility for ...