Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Scientists have developed a powerful new tool to evolve proteins directly within mammalian cells, offering a more effective way to design medical treatments tailored to the human body. (Nanowerk News) ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

In a remarkable leap forward for synthetic biology, the AI model ESM3, developed by Evolutionary Scale, has achieved a significant milestone. By simulating half a billion years of evolutionary ...