In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage ...

CryoEM of frozen membranes has revealed its most intimate folds. Biochemistry of tissue extracts says it bundles up with other secretases. But how does γ-secretase, the all-important enzyme that ...

Expert Rev Neurother. 2009;9(5):661-679. The two characteristic pathological feature of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles, the former being composed of amyloid-ß ...

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for ...

New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric ...

Sunitinib therapy for metastatic melanomas with KIT aberrations. Background: Treatment of metastatic melanoma remains a challenge because most cases are refractory to chemotherapy. The lack of ...

Intensity-modulated radiation therapy for pediatric head and neck rhabdomyosarcoma: French preliminary results. Late side effects of neoadjuvant chemotherapy in patients treated for osteosarcoma and ...

Model of an inhibitor targeted to g-secretase interacting with presenilin. The background shows an Alzheimer's brain that carried a presenilin mutation, with immunohistochemistry revealing abundant ...

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's ...