A crucial feature of adult-onset neurodegenerative diseases is accumulation of abnormal protein in specific brain regions, although the mechanism underlying this pathological selectivity remains ...

Researchers have identified a novel Heat Shock Factor (HSF), designated as HSF5, which plays a crucial role in the completion of meiosis and the activation of genes essential for sperm formation. This ...

Heat shock transcription factors (HSFs) have broad roles in stress resistance that encompass protection from protein misfolding, inflammation and environmental insults. Structural biology studies ...

Researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast ...

CAMBRIDGE, Mass. (August 2, 2012) – Whitehead Institute researchers have found that increased expression of a specific set of genes is strongly associated with metastasis and death in patients with ...

Deletion of hsf5 in mice results in the impaired development of testis (left), and the absence of spermatids and spermatozoa (right), which leads to the failure of sperm formation. Kumamoto University ...