WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...
Bacterial fermentation products with cytostatic and antitumour activity target components of the basal precursor mRNA (pre-mRNA) splicing machinery. At least some of these drugs achieve their effects ...
Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
The initial primary transcripts synthesized by RNA polymerase II (RNAPII) in eukaryotic cells undergo a series of modifications before functional messenger RNAs (mRNAs) exit the nucleus to be ...
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Understanding the Complex Architecture of the Minor Spliceosome
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...
Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten -- ...
Humans share a comparable number of protein-coding genes with the simple roundworm Caenorhabditis elegans, yet we are arguably more sophisticated organisms. This difference in complexity is thanks to ...
This is a preview. Log in through your library . Abstract Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
In a recent paper, a team of researchers explain how the molecular machine known as the spliceosome begins the process of rearranging gene sequences in RNA splicing. Certain diseases such as cystic ...
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