The immune system relies on complex interactions between cells to orchestrate effective responses against pathogens and tumours. Among these, T cells play a pivotal role through their ability to ...

For decades, cancer immunotherapy has focused primarily on CD8 + cytotoxic T lymphocytes as the main executors of tumor cell killing. However, growing clinical and single-cell sequencing evidence ...

The classical paradigm in immunology is that the immune system protects self from non-self. However, there are many cases where the immune system needs to tolerate non-self to avoid complications or ...

The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the ...

SLAMF6 is an immune cell receptor whose function was not clear. Does it activate or inhibit cells? The results so far have been contradictory. Now, scientists at the Institut de Recherches Cliniques ...

Immunotherapy has transformed cancer care, offering a way to harness the body’s own immune system to fight tumors. But even with these advances, many patients still don’t respond. One major barrier to ...

Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion and migration during viral infection, which may inform future therapeutic ...

a complete cycle of natural lactation (21 days) followed by weaning, with tissue analyzed at 28 days after involution when the mammary gland had returned to a pre-pregnancy state (d28-inv mice) early ...