Modification of methyl groups attached to DNA alters gene expression, and mutations that deregulate this methylation are common in some leukaemias. Drugs that target aberrant methylation are emerging ...

Figure 2: Deficiency of Tet2 leads to increased transcripts and decreased A-to-I RNA editing for Socs3. Figure 3: Adar1 binds unmethylated Socs3 mRNA and inhibits Socs3 expression in a Tet2-dependent ...

Scientists have now discovered why a mutation in a gene called TET2 is often implicated in disorders including diabetes, heart disease, stroke, inflammatory diseases, and certain types of cancer. This ...

Approximately 30% of individuals with myeloid malignancy diseases have a mutation in a certain gene called tet methylcytosine dioxygenase 2 (TET2). This gene is responsible for providing instructions ...