Cyclin-dependent kinase 4 - Wikipedia
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a …
CDK4: a master regulator of the cell cycle and its role in cancer
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the …
Targeting CDK4 and CDK6 in cancer - Nature
Mar 18, 2022 · Here, we focus our discussion on emerging concepts in the CDK4/6 field, including a detailed discussion of the biological mechanisms by which CDK4/6 inhibitors exert their effects in …
CDK4 Gene - GeneCards | CDK4 Protein | CDK4 Antibody
Nov 13, 2025 · CDK4, along with its partner CDK6, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research …
CDK4 selective inhibition improves preclinical anti-tumor efficacy and ...
By contrast, CDK4 is dispensable for human bone marrow derived cells, due to the primary and compensatory role of CDK6 in hematopoiesis. This prompted us to develop atirmociclib (PF …
Beyond cell cycle regulation: The pleiotropic function of CDK4 in ...
Jan 1, 2024 · In this review, we focus on the newly reported functions of CDK4, which go beyond direct regulation of the cell cycle. In particular, we describe the extranuclear roles of CDK4, including its …
In Support of CDK4/6 Inhibitors—A Meta-analysis of Available Randomized ...
The recent development of inhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) is arguably one of the most clinically important discoveries for patients living with hormone receptor (HR)–positive, …
Your CDK4/6 Inhibitor Treatment Cycle for Metastatic Breast Cancer: A ...
5 days ago · Learn about the treatment cycle of CDK4/6 inhibitors for metastatic breast cancer with this practical guide, which addresses managing side effects like neutropenia and fatigue via lifestyle ...
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis ...
May 14, 2024 · CDK4, paired with cyclin-D, operates in the long G1 phase, while CDK2 with cyclin-E, manages the brief G1-to-S transition, enabling DNA replication. Aberrant CDK signaling leads to …
Real-world patterns of post-progression treatment and outcomes in ...
Jan 10, 2026 · Factors associated with outcomes in multivariate analysis were the line of CDK4/6i therapy, de novo vs recurrent disease, visceral vs bone-only metastases, and primary endocrine …