Semaglutide - ALZFORUM
Semaglutide is a synthetic, long-acting analog of glucagon-like peptide-1, used to treat diabetes. Ozempic TM is a once-per-week injection formulation, while Rybelsus TM is is a daily pill.
Semaglutide Does Not Treat Alzheimer’s. Could It Prevent Dementia?
Dec 17, 2025 · Semaglutide mildly shifted some CSF AD biomarkers, although the drug is not expected to reduce amyloid. Some scientists believe semaglutide could prevent AD or other dementias, if …
NT-0796 | ALZFORUM
Dec 17, 2025 · Background NT-0796 is an oral, brain-penetrant inhibitor of inflammasomes that contain NLRP3, aka nod-like receptor family pyrin domain-containing protein 3. Inflammasomes are …
Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its ...
Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S. Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies …
The Discovery and Development of Liraglutide and Semaglutide
Knudsen LB, Lau J. The Discovery and Development of Liraglutide and Semaglutide. Front Endocrinol (Lausanne). 2019;10:155. Epub 2019 Apr 12 PubMed.
Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction ...
Rubin R. Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction, Alzheimer Disease, and Other Conditions?. JAMA. 2024 May 14;331 (18):1519-1521. PubMed.
Semaglutide ameliorates cognition and glucose metabolism
Dec 1, 2023 · Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. …
New NLRP3 Inhibitor Acts In Brain to Melt Obesity | ALZFORUM
Oct 23, 2025 · NLRP3 inhibitor must pass into brain to effect weight loss in obese mice. The inhibitor calms microgliosis in the hypothalamus, raising hopes for such effects in other brain areas. TN-783 …
Baseline Characteristics from Evoke and Evoke+: Two Phase 3 …
Scheltens P, Atri A, Feldman H, Hansson O, Knop F, Sano M, Dethlefsen C, Johannsen P, León T, Hansen CT, Cummings J. Baseline Characteristics from Evoke and Evoke+: Two Phase 3 …
Semaglutide ameliorates Alzheimer's disease and restores oxytocin in ...
Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z. Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid …