Regulatory T cells (Tregs) (CD4 CD25 FoxP3 ) are primarily targeted in cancer treatment to reverse their immunosuppressive effects within the tumor microenvironment, which allows tumors to escape immune surveillance. Strategies include depleting intratumoral Tregs, inhibiting their function, or modulating their metabolism to boost anti-tumor immune responses. Key aspects of Treg modulation in cancer treatment: Mechanism of Action: Tumors often show high infiltration of Tregs, which suppress effe
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B. r.... on Instagram: "FoxP3 (Forkhead box P3) gene expression and Regulatory T cells (Tregs) are at the forefront of future therapies for autoimmune diseases, including Type 1 Diabetes (T1D) and rheumatoid arthritis (RA). Tregs are a specialized subset of CD4+ T cells that express the FoxP3 master regulator transcription factor, responsible for suppressing immune responses and maintaining immune tolerance. In autoimmune diseases, these cells are often impaired in number or function, allowing a
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