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Why do red blood cells lyse? Hemolytic anemia comes down to a few major mechanisms. High-yield causes of hemolysis: - Membrane defects → hereditary spherocytosis, elliptocytosis - Enzyme deficiencies → G6PD deficiency, oxidative stress - Hemoglobinopathies → sickle cell disease - Mechanical destruction → prosthetic valves, MAHA (TTP ...
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